STUDY OF BIOACTIVE COMPOUND AND ANTI-PYRETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF SOYMIDA FEBRIFUGA
Prince Sonare, Vishal Shrivastava, Akhlesh Kumar Singhai
ABSTRACT
The present study was undertaken to investigate the bioactive constituents and evaluate the antipyretic activity of the hydroalcoholic extract of Soymida febrifuga. The plant extract was prepared using a hydroalcoholic solvent system, yielding 10.5% w/w extract. Preliminary phytochemical screening revealed the presence of various bioactive compounds including flavonoids, phenols, alkaloids, glycosides, tannins, saponins, and diterpenes. Quantitative estimation showed total flavonoid content of 0.68 mg/100 mg and total phenolic content of 0.92 mg/100 mg of dried extract. The antipyretic activity was evaluated using the Brewer’s yeast-induced pyrexia model in experimental animals. The hydroalcoholic extract was administered at doses of 100 mg/kg and 200 mg/kg body weight, while paracetamol (150 mg/kg) was used as the standard drug. The extract exhibited a dose-dependent reduction in rectal temperature, with the higher dose (200 mg/kg) showing significant antipyretic activity comparable to the standard drug. The results suggest that the antipyretic effect of the extract may be attributed to the presence of flavonoids and phenolic compounds, which are known to inhibit prostaglandin synthesis. In conclusion, the hydroalcoholic extract of Soymida febrifuga possesses significant antipyretic activity and supports its traditional use as a febrifuge. Further studies are required to isolate and characterize the active constituents and to elucidate the precise mechanism of action.
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