FORMULATION AND CHARACTERIZATION OF CANAGLIFLOZIN-LOADED FAST DISSOLVING ORAL FILMS
Ahmed Najib Yahya Qasem, Steffi Thomas, Akhlesh Kumar Singhai
ABSTRACT
The present study aimed to develop and evaluate Canagliflozin-loaded fast dissolving oral films to enhance drug solubility, rapid drug release, and patient compliance. Physical mixtures of the drug were prepared in different ratios to improve solubility, and the results showed a significant increase in solubility, with the highest enhancement observed in the 1:3 ratio. Fast dissolving oral films were prepared using the solvent casting method and evaluated for various physicochemical and mechanical properties. All formulations exhibited uniform thickness, weight, and good transparency, indicating successful film formation. Drug content was found to be within acceptable limits, confirming uniform distribution of the drug. Mechanical properties such as folding endurance and tensile strength demonstrated that the films were strong and flexible. The disintegration time of the films was found to be rapid, with formulation F6 showing the fastest disintegration. In-vitro drug release studies revealed that formulation F6 exhibited maximum drug release (99.25% within 10 minutes), indicating enhanced dissolution behavior. Drug release kinetics followed first-order kinetics, suggesting concentration-dependent release. Stability studies confirmed that the optimized formulation remained stable over a period of three months. In conclusion, the developed fast dissolving oral film of Canagliflozin showed improved solubility, rapid drug release, and good stability, making it a promising drug delivery system for effective management.
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