FORMULATION AND CHARACTERIZATION OF FAST DISSOLVING ORAL WAFERS OF TRIMIPRAMINE USING NATURAL POLYMERS
Viveka Nand Mishra, Gyan Singh, Vivek Gupta
ABSTRACT
The present study aimed to formulate and characterize fast dissolving oral wafers of Trimipramine using natural polymers to enhance patient compliance and rapid drug release. A total of nine formulations (F1–F9) were prepared by the solvent casting method and evaluated for physicochemical and performance parameters. All wafers were found to be translucent with uniform thickness and weight, indicating consistent film formation. The surface pH of all formulations was within the acceptable range, ensuring compatibility with the oral cavity. Folding endurance values indicated good mechanical strength, with F7 showing the highest flexibility. Drug content across all formulations was uniform and within acceptable limits (97–99%). The disintegration time ranged from 15 to 36 seconds, with formulation F7 showing the fastest disintegration. The optimized formulation (F7) exhibited rapid in-vitro drug release, achieving 98.12% release within 300 seconds. Stability studies indicated no significant changes in drug content and release profile under both room and accelerated conditions. Overall, the study demonstrates that natural polymers can be effectively used to develop stable and efficient fast dissolving oral wafers of trimipramine with rapid onset of action and improved patient compliance.
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