FORMULATION & CHARACTERIZATION OF SUSTAINED RELEASE TABLETS OF GENTAMYCIN USING GAUR GUM & XANTHAN GUM
Ashish Kumar Gupta, Trapti Shrivastava, Prithu Pathak, Kuldeep Ganju
ABSTRACT
The present study aimed to develop and evaluate sustained-release floating tablets of Gentamicin using natural polymers, guar gum and xanthan gum, for gastro-retentive drug delivery. Pre-compression parameters of formulations F1–F9 indicated acceptable flowability and compressibility, with bulk density ranging from 0.315–0.335 g/mL, tapped density from 0.432–0.458 g/mL, Carr’s index between 25.28–28.73%, and Hausner’s ratio from 1.338–1.403. Post-compression evaluation revealed uniform tablet thickness (3.37–3.55 mm), adequate hardness (6.4–6.9 kg/cm²), low friability (<1%), acceptable weight variation, and drug content ranging from 96.80–99.25%. All formulations exhibited floating durations exceeding 12 hours, with floating lag times between 50–72 seconds, demonstrating effective gastro-retentive performance. The optimized formulation F5 displayed a controlled release of Gentamicin over 12 hours, achieving 96.4% cumulative drug release. Kinetic modeling indicated that drug release followed the Higuchi model (R² = 0.9866), suggesting diffusion-controlled release, with Korsmeyer–Peppas analysis confirming a non-Fickian transport mechanism. Overall, guar gum and xanthan gum effectively sustained Gentamicin release while ensuring rapid buoyancy and prolonged floating, making F5 a promising formulation for gastro-retentive therapy.
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