FORMULATION APPROACHES AND EVALUATION OUTCOMES OF BILAYERED TABLETS FOR ANTIHYPERTENSIVE DRUGS: A REVIEW
Sadhana Verma, Satkar Prasad
ABSTRACT
Bilayered tablets represent an advanced oral dosage form that enables the delivery of two drugs simultaneously or allows sequential release profiles for a single active pharmaceutical ingredient (API). This approach is particularly useful for antihypertensive therapy, where combination therapy is often required to achieve optimal blood pressure control. This review highlights recent advancements in the formulation strategies, characterization, and evaluation of bilayered tablets containing antihypertensive drugs such as Amlodipine, Perindopril, Valsartan, and others. Various formulation approaches, including immediate-release (IR) and sustained-release (SR) layers, use of superdisintegrants, hydrophilic polymers, and gastro-retentive strategies, are summarized. Evaluation outcomes such as disintegration time, in vitro dissolution, drug release kinetics, stability, and bioavailability are discussed. The review demonstrates that bilayer tablet technology offers improved patient compliance, optimized therapeutic efficacy, and enhanced pharmacokinetic profiles.
[Full Text Article]