DESIGN, DEVELOPMENT AND EVALUATION OF HERBAL CREAM CONTAINING CENTELLA ASIATICA, CINNAMOMUM ZEYLANICUM, AND CURCUMA LONGA FOR MELASMA TREATMENT
Avadhesh Sahu, Sunil Kumar Jain, Vivek Kumar Jain, Rupesh Kumar Jain, Mansha Singhai
ABSTRACT
The present study aimed to develop and evaluate a polyherbal cream using extracts of Centella asiatica, Cinnamomum zeylanicum, and Curcuma longa for antioxidant and topical applications. Six formulations (F1–F6) were prepared using the fusion method, varying concentrations of stearic acid and cetyl alcohol while keeping the amount of plant extracts constant. Physico-chemical parameters, extractive values, and phytochemical profiles of the herbal ingredients were determined. The formulation F6 showed desirable physicochemical properties with a pH of 6.85, high drug content (99.12%), smooth and glossy texture, and appropriate viscosity (32,100 cP). The antioxidant potential was evaluated using the DPPH radical scavenging assay, where formulation F6 showed significant activity (82.17% inhibition at 100 µg/ml) with an IC?? of 50.54 µg/ml. The results suggest that the developed herbal cream, particularly formulation F6, exhibits potent antioxidant activity and favorable physical characteristics, making it a promising candidate for skin care applications.
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