FORMULATION AND CHARACTERIZATION OF SURFACE MODIFIED DRUG DELIVERY SYSTEM BEARING SUMATRIPTAN
Aaditya Saini, Sunil Kumar Jain, Vivek Kumar Jain, Mansha Singhai, Rupesh Kumar Jain
ABSTRACT
The present study focuses on the formulation and characterization of mucoadhesive nanoparticles of Sumatriptan for enhanced nasal drug delivery. Sumatriptan, a selective serotonin receptor agonist, is widely used in the treatment of migraine but suffers from poor oral bioavailability due to extensive first-pass metabolism. To overcome this limitation, mucoadhesive nanoparticles were developed using chitosan and sodium tripolyphosphate via the ionic gelation method. A series of six formulations (F1–F6) were prepared and evaluated for percentage yield, drug entrapment efficiency, particle size, zeta potential, mucoadhesive strength, and in vitro drug release. Among the formulations, F6 was found to be optimal, exhibiting a high percentage yield (83.32%), drug entrapment efficiency (80.32?±?0.54%), and mucoadhesive strength (78.98?±?0.85%). The optimized formulation showed spherical morphology with a uniform particle distribution under scanning electron microscopy and a particle size in the acceptable nanoscale range. In vitro drug release studies demonstrated a sustained release of Sumatriptan up to 12 hours, with 99.02% cumulative drug release. The release kinetics followed the Korsmeyer-Peppas model, indicating a non-Fickian mechanism involving both diffusion and polymer matrix erosion. These findings suggest that chitosan-based mucoadhesive nanoparticles could serve as an efficient nasal delivery system for Sumatriptan, potentially improving its bioavailability and therapeutic efficacy in migraine treatment.
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