PHYTOCHEMICAL SCREENING AND IN VIVO ANTIDIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT LEAVES OF LILIUM CANDIDUM
Abhay Rawat, Arpit Shrivastava, Prateek Kumar Jain, Harshita Jain
ABSTRACT
The present study aimed to evaluate the phytochemical composition and antidiabetic potential of the hydroalcoholic leaf extract of Lilium candidum in streptozotocin-induced diabetic rats. Preliminary phytochemical screening confirmed the presence of bioactive compounds including alkaloids, phenols, saponins, and proteins. Quantitative estimations revealed substantial levels of total alkaloids and phenolic content. In vivo experiments demonstrated that oral administration of the extract at doses of 100 and 200 mg/kg for 30 days significantly reduced blood glucose levels, improved serum insulin, and decreased glycosylated hemoglobin levels in diabetic rats. Additionally, the extract positively modulated lipid profiles by reducing total cholesterol and triglyceride levels. The results were comparable to those observed with the standard drug glibenclamide. These findings support the traditional use of Lilium candidum as an antidiabetic agent and encourage further studies for its development as a natural therapeutic option for diabetes management.
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