FORMULATION AND CHARACTERIZATION OF BILAYER TABLETS OF CINNARIZINE AND DOMPERIDONE
Ritesh Kumar Bhakt, Sandesh Asati, Vishnu Raj, Brijesh Sirohi
ABSTRACT
The objective of the present study was to formulate and evaluate bilayer tablets of Cinnarizine and Domperidone to achieve both immediate and sustained drug release from a single dosage form. The immediate-release layer containing Cinnarizine was prepared using suitable superdisintegrants, while the sustained-release layer of Domperidone was developed using hydrophilic polymers. The prepared tablets were evaluated for pre- and post-compression parameters, disintegration time, drug content, and in-vitro drug release studies. All formulations showed acceptable physicochemical properties within pharmacopeial limits. Among the immediate-release batches, formulation IF6 exhibited the fastest disintegration time (63 ± 4 sec) with satisfactory drug content. The optimized sustained-release formulation (F6) provided controlled drug release up to 12 hours. The bilayer tablet demonstrated rapid release of Cinnarizine (98.85% within 1.5 h) and sustained release of Domperidone (98.85% at 12 h), confirming the dual-release objective. The findings indicate that bilayer tablets of Cinnarizine and Domperidone can serve as a promising dosage form, offering both immediate symptomatic relief and prolonged therapeutic effect, thereby improving patient compliance and treatment effectiveness in motion sickness.
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