FORMULATION AND CHARACTERIZATION OF TOBRAMYCIN SUSTAINED RELEASE TABLETS
Aaradhana Vishwakarma, Sandesh Asati, Vishnu Raj, Brijesh Sirohi
ABSTRACT
The present study aimed to formulate and evaluate sustained release floating tablets of Tobramycin to improve gastric retention, enhance bioavailability, and reduce dosing frequency. Pre-compression parameters of the powder blend, including bulk density, tapped density, compressibility index, and Hausner’s ratio, indicated satisfactory flow properties for tablet formulation. Post-compression evaluation revealed uniform weight, thickness, hardness, friability below 1%, and acceptable drug content (96.65–99.12%). Floating studies confirmed a floating lag time between 48–74 seconds with a total buoyancy period exceeding 12 hours. In-vitro drug release studies demonstrated sustained release up to 12 hours, with formulation F5 showing the most optimized release profile (98.1% at 12 hours). Kinetic modeling indicated that drug release followed the Higuchi model (R² = 0.9869), with Korsmeyer–Peppas analysis suggesting a non-Fickian diffusion mechanism. The results confirmed that the optimized formulation (F5) provided effective gastroretentive properties and sustained release characteristics, making it a promising candidate for enhancing therapeutic efficacy and patient compliance in Tobramycin therapy.
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