FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING BEADS OF ROXATIDINE ACETATE
Ankit Patel, Sandesh Asati, Vishnu Raj, Brijesh Sirohi
ABSTRACT
The present study was aimed at the formulation and evaluation of floating beads of Roxatidine acetate for the treatment of gastric disorders. Floating drug delivery systems are designed to prolong the gastric residence time, improve bioavailability, and ensure controlled release of the drug at its absorption site. Floating beads were prepared using ionotropic gelation technique with calcium chloride as a crosslinking agent and citric acid as a gas-forming agent. The formulated beads were evaluated for flow properties, particle size, entrapment efficiency, swelling index, and in-vitro drug release. Flow property analysis confirmed good compressibility and flow with Carr’s index ranging from 25.62% to 31.02% and Hausner’s ratio between 1.345–1.450. The particle size of beads ranged between 280.36–345.65 nm, with maximum entrapment efficiency observed for F4 (79.98%). Swelling index studies indicated a gradual increase in swelling up to 163% at 8 hours for F4, supporting sustained drug release. In-vitro release studies demonstrated controlled drug release, with F4 showing 99.05% release at 12 hours. Drug release kinetics followed first-order (r² = 0.9948) and Korsmeyer-Peppas model (r² = 0.9681), suggesting diffusion-controlled release. The results confirmed that the optimized formulation F4 provided prolonged gastric residence and sustained release, indicating its potential as an effective floating drug delivery system for Roxatidine acetate.
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