ANTI- INFLAMMATORY ACTIVITY OF EQUAL PROPORTION OF DIFFERENT SOLVENT EXTRACT OF CALOTROPIS GIGANTEA LEAVES & ROOTS
Kumari Diwya, B. K. Dubey, Deepak Kumar Basedia
ABSTRACT
The present study investigates the anti-inflammatory and anti-arthritic potential of hydroalcoholic extracts derived from the leaves and roots of Calotropis gigantea, administered in equal proportions. The extracts were evaluated for percentage yield, phytochemical constituents, and total bioactive content including phenols and flavonoids. Preliminary phytochemical screening revealed the presence of various secondary metabolites such as flavonoids, glycosides, saponins, tannins, and phenolic compounds, which are known to contribute to anti-inflammatory activity. Quantitative analysis indicated a higher phenolic content in leaves and higher flavonoid content in roots. The anti-arthritic activity was assessed using the Freund’s adjuvant-induced arthritis model in Wistar rats. Animals treated with the plant extract at doses of 100 mg/kg and 200 mg/kg showed a significant and dose-dependent reduction in paw edema over a 28-day period, compared to the untreated arthritic control group. The effect observed at 200 mg/kg was comparable to the standard drug aspirin. The results suggest that the hydroalcoholic extract of Calotropis gigantea exhibits promising anti-inflammatory activity and may serve as a potential natural alternative for managing inflammatory and arthritic conditions.
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