FORMULATION AND EVALUATION OF VILDAGLIPTIN LOADED BIO-ADHESIVE MICROSPHERES
Vanshika Daniel, Garima Indurkhya, Dr. S. Nayak
ABSTRACT
The objective of this study was to formulate and evaluate bioadhesive chitosan microspheres of Vildagliptin for sustained drug delivery. Microspheres were prepared by the ionotropic gelation method using chitosan and sodium tripolyphosphate as crosslinking agents. Six different formulations (F1–F6) were developed by varying polymer concentrations. The prepared microspheres were evaluated for percentage yield, entrapment efficiency, particle size, zeta potential, flow properties, and in vitro drug release. Among the formulations, F3 showed the highest entrapment efficiency (73.32?±?0.15%) and percentage yield (72.45?±?0.36%). In vitro drug release studies demonstrated that the chitosan microspheres could sustain the release of Vildagliptin over 12 hours compared to the immediate release from the plain drug. Kinetic modeling revealed that drug release followed zero-order kinetics and a diffusion-controlled mechanism. The findings suggest that bioadhesive microspheres offer a promising strategy for the controlled delivery of Vildagliptin, potentially enhancing its therapeutic efficacy.
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