FORMULATION, DEVELOPMENT OF TRANSDERMAL PATCHES OF ANTIDIABETIC DRUG FOR MANAGEMENT OF TYPE 2 DIABETES
Gayatri Dahariya
ABSTRACT
The present study focuses on the formulation and evaluation of transdermal patches containing Saxagliptin, an antidiabetic agent, for the effective management of type 2 diabetes mellitus. The patches were developed using various polymers, including Eudragit L-100, Ethyl Cellulose, and HPMC, through the solvent casting method. Propylene glycol was used as a plasticizer and permeation enhancer. The prepared patches were evaluated for physicochemical parameters such as thickness, moisture uptake, folding endurance, and drug content, all of which were found within acceptable limits. The optimized formulation (F4) exhibited desirable mechanical properties and sustained drug release up to 12 hours, reaching 98.98% cumulative release. The drug release followed zero-order kinetics and fitted well into the Korsmeyer-Peppas model, indicating non-Fickian diffusion. The findings suggest that Saxagliptin transdermal patches offer a promising alternative for controlled and sustained drug delivery in the treatment of type 2 diabetes, improving patient compliance and therapeutic efficacy.
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