DEVELOPMENT AND EVALUATION OF NOVEL COMBINATION FORMULATION FOR TOPICAL TREATMENT OF SKIN DISORDER
Abhijeet Shrivastava, Abhishek Kaithwas, Abhay Gupta, Abhishek Singh Bichhaile, Rakesh Gawaly
ABSTRACT
This study focused on the development and evaluation of a topical cream formulation containing Clobetasol Propionate (CP) and Salicylic Acid (SA) for the treatment of dermatological conditions. A systematic approach was used, including preformulation studies to assess drug-excipient compatibility, formulation development using an oil-in-water emulsion system, and comprehensive physicochemical evaluations. The formulation demonstrated optimal properties such as suitable pH, viscosity, spreadability, and drug content uniformity. In vitro studies showed sustained drug release and effective skin permeation, indicating potential for transdermal delivery. Stability testing confirmed the formulation’s physical, chemical, and microbial stability over three months under ICH conditions. Overall, the developed formulation presents a stable and effective vehicle for CP and SA, offering promise for treating inflammatory and hyperkeratotic skin disorders. Further clinical trials are recommended to establish its therapeutic efficacy.
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