IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

STUDY OF DIFFERENT DRUG WHICH GIVE TERATOGENICITY EFFECTS IN PREGNANCY

Vivek Dwivedi,  Purnima Tripathi, Dr. S. Nayak

ABSTRACT

Teratogenicity refers to the capability of certain substances, including drugs, to cause congenital abnormalities or malformations in a developing fetus. This study explores the historical context, mechanisms, and various categories of teratogenic agents with a particular focus on pharmaceutical drugs. The investigation covers commonly prescribed medications such as ACE inhibitors, NSAIDs (like diclofenac), thalidomide, antineoplastic agents, antiepileptic drugs (e.g., valproic acid), anticoagulants (e.g., warfarin), and retinoids, examining their teratogenic mechanisms and effects. The study also discusses chemical agents (e.g., alcohol, cocaine, methyl mercury, lead), maternal factors like diabetes and epilepsy, and physical agents including cigarette smoke and ionizing radiation, all of which contribute to fetal anomalies. Notable congenital conditions such as spina bifida, hypocalvaria, fetal alcohol spectrum disorders (FASD), polydactyly, facial dysmorphia, and clubfoot are highlighted as outcomes of these exposures. Understanding the mechanisms of teratogenicity, critical exposure periods, and the importance of prevention strategies is crucial for minimizing risk during pregnancy. This study reinforces the need for healthcare professionals to critically assess the risk-benefit profile of medications prescribed during pregnancy.

[Full Text Article]

Journal Front Page

cover

Current News

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in IJPDR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for June supplimentry issue 2023

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

     

  • Article Invited for December supplimentry issue 2023

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

     

  • Article Invited for June supplimentry issue 2024

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

  • Article Invited for December issue 2024

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

  • Article Invited for June issue 2025

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com