FORMULATION AND EVALUATION OF NYSTATIN LOADED INVASOMES GEL FOR MANGMENT OF TOPICAL DISESASE
Gunjan Harode, Sweety Tiwari, Akhlesh Kumar Singhai
ABSTRACT
The present study focuses on the formulation and evaluation of a Nystatin-loaded invasomal gel for the effective treatment of topical fungal infections. Invasomes, flexible vesicular carriers composed of phospholipids, ethanol, and terpenes, were employed to enhance the skin penetration and bioavailability of Nystatin. Six different invasomal formulations (N1–N6) were prepared and characterized for vesicle size and entrapment efficiency, with formulation N2 showing the best results. The optimized invasomal formulation was then incorporated into a Carbopol 934P-based gel, and further evaluated for physicochemical parameters, drug content, spreadability, viscosity, and in vitro drug release. The optimized gel formulation (IG2) exhibited controlled drug release over 12 hours, following first-order kinetics, and showed good stability over six months. The findings suggest that invasomal gel is a promising topical delivery system for antifungal therapy, offering better patient compliance and therapeutic outcomes compared to conventional formulations.
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