FORMULATION AND DEVELOPMENT OF ORODISPERSIBLE TABLETS (ODTS) OF AN ANTI-ALZHEIMER DRUG GALANTAMINE
Hariom Gupta, Himanshu Kumar, Gopal Kumar, Harsh Vishwakarma, Namrata Soni
ABSTRACT
The development and evaluation of Orodispersible Tablets (ODTs) of Galantamine, an anti-Alzheimer drug, were conducted to improve patient compliance and therapeutic efficacy. Galantamine is used to manage cognitive symptoms in Alzheimer's disease by increasing acetylcholine levels in the brain. Traditional tablet formulations can present difficulties in administration, especially for patients with swallowing problems. Therefore, the aim was to formulate an ODT that disintegrates rapidly in the oral cavity without the need for water. The tablets were evaluated for critical quality control parameters, including weight variation, friability, disintegration time, and dissolution rate. The results showed that the tablets met the official pharmacopeial standards. The weight variation was within the acceptable ±10%, with a low friability of 0.114%, indicating good mechanical strength. The tablets disintegrated within 38.45 ± 1.54 seconds, which is ideal for rapid drug release. Additionally, the dissolution rate exceeded the required 80%, confirming efficient drug release. These results suggest that the developed Galantamine ODT formulation is stable, effective, and provides an alternative that enhances patient compliance in treating Alzheimer's disease.
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