STUDY OF PLANTS SECONDARY METABOLITES AND ANTIULCER ACTIVITY OF ACACIA MODESTA LEAVES EXTRACT
Arya Raj, Dr. Pradeep Kumar Mohanty
ABSTRACT
The present study was undertaken to evaluate the phytochemical composition and antiulcer activity of the hydroalcoholic extract of Acacia modesta leaves. The extract was prepared using successive solvent extraction, with a maximum yield of 7.25% obtained from the hydroalcoholic solvent system. Preliminary phytochemical screening revealed the presence of flavonoids, phenols, proteins, carbohydrates, and tannins, while alkaloids and saponins were absent. Quantitative estimation confirmed notable amounts of flavonoids (0.952 mg/100 mg) and phenols (0.645 mg/100 mg). The antiulcer potential was assessed using the ethanol-induced ulcer model in rats. The extract demonstrated a significant, dose-dependent reduction in ulcer index, comparable to the standard antiulcer drug, Ranitidine. The treated groups showed a marked increase in gastric pH and a decrease in total acidity, free acidity, and pepsin activity. These findings suggest that the hydroalcoholic extract of Acacia modesta leaves possesses promising antiulcer activity, likely attributed to its phytoconstituents with antioxidant and gastroprotective properties.
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