DEVELOPMENT AND EVALUATION OF PHYTOSOMES AND POLYHERBAL FORMULATION OF SOME RASAYANA PLANTS FOR EFFECTIVE TREATMENT OF HEPATIC DISEASES
Dr. Mamta Yadav, Dr. S. Nayak
ABSTRACT
The aim of this study was to develop and evaluate phytosome formulations from three Rasayana plants, Withania somnifera, Emblica officinalis, and Terminalia bellirica, for their hepatoprotective potential in the treatment of hepatic diseases. Phytosomes, a novel drug delivery system, were prepared to enhance the bioavailability and stability of the active ingredients from these plants. Various solvents were used to extract the bioactive compounds, and the extracts were subjected to phytochemical screening to identify key constituents such as flavonoids, saponins, and diterpenes. The prepared phytosome formulations were characterized for particle size, entrapment efficiency, and drug release kinetics. In vivo hepatoprotective activity was assessed using CCl4-induced liver toxicity in rats. The results indicated that phytosome formulations, especially the mixed polyherbal formulation, exhibited significant hepatoprotective effects, as evidenced by improved body weight gain and reduced SGPT and SGOT levels. The study demonstrates the potential of phytosomal formulations as effective therapeutic agents for liver protection, enhancing the pharmacological activity of Rasayana plants.
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