IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING MICROBALLONS OF LAFUTIDINE

Amir Sohail, Prithu Pathak, Trapti Shrivastava

ABSTRACT

Floating microballoons loaded with Lafutidine were formulated and evaluated for their potential as gastroretentive drug delivery systems. Various formulations (F1-F6) were prepared and characterized for yield, drug entrapment, buoyancy, and in vitro release kinetics. Among them, formulation F5 exhibited a high yield of 75.65% and efficient drug entrapment of 74.65% w/w. It demonstrated a short floating lag time of 52 seconds and high buoyancy (93%), indicating prolonged gastric retention. Particle size analysis confirmed uniform distribution, while SEM imaging revealed spherical morphology. In vitro release studies showed sustained drug release over 12 hours, fitting well with diffusion-controlled models (R² > 0.98). Formulation F5 holds promise for enhancing Lafutidine’s bioavailability and therapeutic efficacy through controlled and sustained drug release.

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