IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF ANTIEMETIC DRUG

Kalyani Tamrakar, V. P. Gupta, Bhupendra Tiwari

ABSTRACT

The aim of this study was to formulate and evaluate fast-dissolving tablets (FDTs) of Metoclopramide, an antiemetic drug, to improve patient compliance, especially for those who have difficulty swallowing tablets. Various formulations of Metoclopramide FDTs were prepared using different excipients, including sodium starch glycolate, croscarmellose sodium, and magnesium stearate, through direct compression. Pre-compression parameters such as loose bulk density, tapped bulk density, Carr’s index, and Hausner’s ratio were determined to assess the powder flowability. Post-compression parameters including hardness, friability, weight variation, thickness, and drug content were evaluated, showing that all formulations met the official standards for fast-dissolving tablets. The disintegration time of the formulations ranged from 65 to 96 seconds, with F3 showing the fastest disintegration (65 ± 4 seconds). In-vitro drug release studies revealed that F3 exhibited nearly complete release of Metoclopramide (98.74%) within 15 minutes. The release data followed the Higuchi model, indicating a diffusion-controlled release mechanism. The optimized formulation F3 demonstrated excellent characteristics, including rapid disintegration, optimal drug release, and good physical properties. These findings suggest that F3 is a promising formulation for rapid antiemetic relief and can enhance patient compliance.

[Full Text Article]

Journal Front Page

cover

Current News

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in IJPDR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for June supplimentry issue 2023

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

     

  • Article Invited for December supplimentry issue 2023

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

     

  • Article Invited for June supplimentry issue 2024

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

  • Article Invited for December issue 2024

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

  • Article Invited for June issue 2025

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com