REVIEW ON CONTROLLED DRUG DELIVERY SYSTEMS
Md. Anas Mansoori, Chandra Chaurasia, B. K. Dubey
ABSTRACT
Controlled drug delivery systems (CDDS) represent a significant advancement in the field of pharmacology, offering sustained and targeted delivery of therapeutic agents to improve the effectiveness and safety of treatment. These systems are designed to release drugs at a predetermined rate, maintaining therapeutic drug concentrations for extended periods and minimizing side effects. CDDS can be classified into various types, including oral, transdermal, injectable, and implantable systems, each designed to meet specific clinical requirements. The mechanisms behind CDDS, such as diffusion, erosion, and swelling, play crucial roles in determining the release profiles of drugs. Furthermore, the materials used for constructing CDDS, including polymers, lipids, and nanoparticles, have seen significant evolution to enhance biocompatibility, stability, and controlled release properties. This review article discusses the different types of controlled drug delivery systems, their mechanisms, and their applications in the treatment of chronic diseases, cancer therapy, and personalized medicine. The challenges in designing efficient CDDS, such as patient compliance, stability, and regulatory hurdles, are also addressed. Finally, the future prospects of CDDS, including the integration of nanotechnology and stimuli-responsive materials, are discussed as promising strategies for improving drug delivery systems.
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