FORMULATION OF METOCLOPRAMIDE SUSTAINED RELEASE TABLETS USING NATURAL GUMS
Mrityunjay Singh, Deepak Mishra, Narottam Singh Kushwah, Murari Lal, Avinash Krishnarao Kondalkar
ABSTRACT
The objective of this study was to formulate and evaluate Metoclopramide sustained-release tablets using floating drug delivery systems (FGR) to enhance the therapeutic efficacy of the drug by prolonging its gastric retention time. Various formulations were developed and characterized based on their pre-compression and post-compression properties, in-vitro buoyancy, and drug release profiles. The floating lag time of the formulations varied from 33 seconds (F7) to 69 seconds (F1), with F7 showing the shortest lag time. The in-vitro drug release study revealed that Formulation F7 achieved 99.74% drug release within 12 hours, making it the most promising formulation for sustained release. Regression analysis showed that F7 exhibited the best fit to the Peppas model (R² = 0.9529), indicating that a combination of diffusion and polymer erosion controlled the drug release. Post-compression evaluation demonstrated acceptable values for tablet hardness, friability, and drug content, confirming the physical integrity and content uniformity of the tablets. The study concluded that Formulation F7 is the optimal candidate for a Metoclopramide sustained-release floating tablet, offering controlled drug release, excellent floating behavior, and good pharmacotechnical properties, which can improve patient compliance in the treatment of gastrointestinal disorders.
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