DEVELOPMENT AND CHARACTERIZATION OF NANOCARRIER RIFABUTIN CONTAINING SOLID LIPID NANOPARTICLES FOR THE TREATMENT OF TUBERCULOSIS
Anas Khan Rangrej, Sameer Pandey, Sunil K. Jain
ABSTRACT
This research focuses on the development and characterization of Rifabutin-loaded solid lipid nanoparticles (SLNs) for improved tuberculosis treatment. Rifabutin, an effective anti-tubercular agent, was encapsulated in SLNs using a microemulsion technique. The study optimized various formulation parameters, including lipid composition and surfactant concentration, to achieve a stable and effective delivery system. The optimized formulation (F14) demonstrated a particle size of 210.25 nm, an entrapment efficiency of 77.74%, and a zeta potential of -37.85 mV, indicating good stability. Drug release studies revealed a controlled and sustained release of Rifabutin, with 93.32% of the drug released over 12 hours, following a zero-order release mechanism. Stability testing confirmed that the formulation remained stable over three months at different temperatures. These results suggest that Rifabutin-loaded SLNs provide an effective and stable method for tuberculosis treatment, offering enhanced drug delivery and sustained release.
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