FORMULATION AND EVALUATION OF OPHTHALMIC DELIVERY SYSTEM OF LOTEPREDNOL ETABONATE
Ashish Rajput, Bhupendra Tiwari, V. P. Gupta
ABSTRACT
The objective of this study was to formulate and evaluate an ophthalmic delivery system for Loteprednol Etabonate (LE) to enhance its therapeutic efficacy in treating ocular conditions. Various formulations were developed and characterized for pH stability, drug content, sol-gel transition temperature, viscosity, and release profiles. Results indicated that formulations maintained a physiologically compatible pH, with drug content ranging from 77.06% to 83.82%. The optimized formulation (F10) exhibited a controlled in vitro release profile, achieving 68.906% cumulative drug release over 12 hours. Stability studies revealed consistent pH and viscosity over 60 days, confirming the formulation's robustness. The findings suggest that the developed system could improve patient compliance and therapeutic outcomes in ocular therapy.
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