CHEMICAL EVALUATION AND PREVENTIVE POTENTIAL OF KALANCHOE PINNATA IN CCL4 INDUCED HEPATOTOXICITY
Amit Vishwas, Harshita jain, Arpit Shrivastava, Ajay Yadav, Vaishali Yadav
ABSTRACT
The present study investigates the chemical composition and hepatoprotective potential of Kalanchoe pinnata against carbon tetrachloride (CCl4)-induced hepatotoxicity in albino rats. A hydro-alcoholic extract of Kalanchoe pinnata was prepared, yielding 13.57 ± 1.18%. Phytochemical screening revealed the absence of carbohydrates, alkaloids, triterpenoids, steroids, saponins, tannins, phenolic compounds, flavonoids, and glycosides, while the presence of oils was confirmed. To assess the hepatoprotective effects, serum parameters, including SGOT, SGPT, SALP, and SBLN, were measured in different groups of rats. Results demonstrated a significant increase in these markers in the toxin control group when compared to the normal group, confirming hepatotoxicity. However, treatment with K. pinnata extract at both low and high doses resulted in a significant reduction in these markers, indicating its protective effect. The low dose extract group showed the highest percentage recovery in SGOT (51.69%), SGPT (92.47%), SALP (72.50%), and SBLN (105.50%), suggesting a dose-dependent hepatoprotective effect. These findings highlight the potential of Kalanchoe pinnata as a natural therapeutic agent for preventing liver damage caused by toxic agents like CCl4.
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