IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

DEVELOP AND CHARACTERIZE CELECOXIB-LOADED LIPOSOMES FOR THE EFFECTIVE MANAGEMENT OF RHEUMATOID ARTHRITIS

Abhay Singh Dangi, Rohit Ghoshi, Sunil K. Jain

ABSTRACT

This study focuses on the formulation and characterization of Celecoxib-loaded liposomes aimed at enhancing the management of rheumatoid arthritis. Celecoxib, a selective COX-2 inhibitor, is poorly soluble in water, which limits its therapeutic efficacy. To address this, liposomes were prepared using phosphatidylcholine and cholesterol to encapsulate Celecoxib, optimizing parameters such as vesicle size and entrapment efficiency. The optimized formulation (F5) exhibited a vesicle size of 110.25 nm and an entrapment efficiency of 85.64%. Additionally, liposomal gel formulations were developed, showing desirable characteristics including appropriate pH, high drug content, and good spreadability. In vitro release studies demonstrated a controlled drug release profile, with 98% of Celecoxib released over 10 hours, indicating sustained therapeutic action. Regression analysis suggested the release mechanism follows a non-Fickian diffusion model. These results highlight the potential of Celecoxib-loaded liposomes as an effective drug delivery system, improving bioavailability and therapeutic outcomes in rheumatoid arthritis management. Further studies are warranted to evaluate the in vivo efficacy of this innovative formulation.

[Full Text Article]

Journal Front Page

cover

Current News

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in IJPDR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for June supplimentry issue 2023

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

     

  • Article Invited for December supplimentry issue 2023

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com

     

  • Article Invited for June supplimentry issue 2024

      Dear Researcher, 
      Article also invited for the Next coming Issue from your side. For More details Visit: www.ijpdr.com. You can find the article on http://ijpdr.com/current_issue.php
      For More details Visit: www.ijpdr.com