DEVELOP AND CHARACTERIZE CELECOXIB-LOADED LIPOSOMES FOR THE EFFECTIVE MANAGEMENT OF RHEUMATOID ARTHRITIS
Abhay Singh Dangi, Rohit Ghoshi, Sunil K. Jain
ABSTRACT
This study focuses on the formulation and characterization of Celecoxib-loaded liposomes aimed at enhancing the management of rheumatoid arthritis. Celecoxib, a selective COX-2 inhibitor, is poorly soluble in water, which limits its therapeutic efficacy. To address this, liposomes were prepared using phosphatidylcholine and cholesterol to encapsulate Celecoxib, optimizing parameters such as vesicle size and entrapment efficiency. The optimized formulation (F5) exhibited a vesicle size of 110.25 nm and an entrapment efficiency of 85.64%. Additionally, liposomal gel formulations were developed, showing desirable characteristics including appropriate pH, high drug content, and good spreadability. In vitro release studies demonstrated a controlled drug release profile, with 98% of Celecoxib released over 10 hours, indicating sustained therapeutic action. Regression analysis suggested the release mechanism follows a non-Fickian diffusion model. These results highlight the potential of Celecoxib-loaded liposomes as an effective drug delivery system, improving bioavailability and therapeutic outcomes in rheumatoid arthritis management. Further studies are warranted to evaluate the in vivo efficacy of this innovative formulation.
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