PHARMACOLOGICAL SCREENING OF CURCUMA LONGA IN OBESITY COMORBID WITH DEPRESSION
Ankita Yadav, Harshita Jain, Arpit Shrivastava, Mansha Jain, Sunil Kumar Jain, Vaishali Yadav
ABSTRACT
This study investigates the pharmacological effects of Curcuma longa (Turmeric) in a mouse model of obesity comorbid with depression. Using a hydro-ethanolic extract of the rhizome, we assessed the yield and conducted phytochemical analysis, which revealed the presence of glycosides and saponins. The impact of C. longa on locomotor activity, immobility time in forced swimming and tail suspension tests, and biochemical parameters was evaluated. Mice on a high-fat diet (HFD) exhibited reduced locomotor activity and increased immobility time, indicating depressive-like behavior. Treatment with C. longa extract significantly improved locomotor activity and reduced immobility times, particularly at a dosage of 400 mg/kg. Additionally, C. longa administration lowered glucose, triglycerides, and cholesterol levels in HFD-fed mice. These findings suggest that Curcuma longa possesses potential therapeutic effects in alleviating obesity and associated depressive symptoms.
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