ENHANCEMENT OF SOLUBILITY AND DEVELOPMENT OF FAST DISSOLVING ORAL FILM OF NIFEDIPINE
Sanjeev Kumar, Samreen Ali, Ashish Manigauha
ABSTRACT
The study aimed to enhance the solubility of nifedipine and develop fast-dissolving oral films for improved therapeutic efficacy. Nifedipine was formulated with solubilizing agents, polyethylene glycol (PEG 400) and polyvinylpyrrolidone (PVP K-90), to increase solubility. The physical mixture showed significant solubility enhancement, with PVP K-90 yielding a maximum increase of 270.52%. Six formulations of oral films were prepared using hydroxypropyl methylcellulose (HPMC) as the polymer matrix. Evaluation of the films indicated acceptable mechanical properties, rapid disintegration times, and satisfactory drug content. The optimized formulation demonstrated 96.65% cumulative drug release within 15 minutes. Stability studies confirmed the films' potency over three months. These findings suggest that nifedipine-loaded fast-dissolving oral films may offer an effective alternative for rapid drug delivery.
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