FORMULATION AND CHARACTERIZATION OF VORICONAZOLE-LOADED INVASOMES FOR EFFECTIVE ANTI - FUNGAL ACTIVITY
Som Gupta, Kaushelendra Mishra, Richa Verma, Mehta Parulben Durgashankar, Tushar Singh
ABSTRACT
This study focuses on the formulation and characterization of Voriconazole-loaded invasomes to enhance antifungal activity. Voriconazole, an effective antifungal agent, was encapsulated using soya phosphatidylcholine and characterized for entrapment efficiency, vesicle size, and gel properties. The formulations exhibited high entrapment efficiency, with the optimized formulation (F6) achieving 88.95% and a vesicle size of 225.45 nm. The invasomes gel demonstrated suitable viscosity, pH, drug content, and spreadability, confirming its potential for topical applications. In vitro drug release studies indicated a sustained release profile, with 99.44% of the drug released after 12 hours, suggesting effective delivery. Release kinetics analysis revealed a diffusion-controlled mechanism. Overall, voriconazole-loaded invasomes present a promising approach for improved antifungal therapy.
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