FORMULATION AND CHARACTERIZATION OF POLYMERIC NANOGEL OF ANTIFUNGAL DRUG VORICONAZOLE
Gaurav Khasdev, Ruchi Gaikwad, Kavita R. Loksh
ABSTRACT
This study focuses on the formulation and characterization of a polymeric nanogel for the antifungal drug voriconazole. Various formulations were developed and assessed for physical characteristics, including washability, extrudability, spreadability, viscosity, and drug content. Among the tested formulations, F4 exhibited the most favorable attributes, including optimal viscosity (4258 cps) and a high drug content (99.65%). The cumulative drug release study demonstrated that formulation F4 achieved 90% drug release over 240 minutes, indicating effective drug encapsulation and controlled release. Kinetic analysis revealed that the release followed a first-order mechanism (R² = 0.9971). These findings suggest that the developed voriconazole-loaded nanogel has the potential for enhanced therapeutic efficacy in the treatment of fungal infections.
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