FORMULATION AND CHARACTERIZATION OF PHOSPHOLIPID COMPLEX OF PIPER CUBEBA
Jubbair Ahmad, Rajeev Kumar Malviya
ABSTRACT
This study focuses on the formulation and characterization of phospholipid complexes of Piper cubeba to enhance the bioavailability of its bioactive constituents. Various formulations were optimized by varying the ratios of phospholipids and cholesterol, extract concentrations, and dichloromethane concentrations. The hydroalcoholic extract yielded a percentage of 10.5%, containing significant phytochemicals, including flavonoids and phenols. The optimized formulation demonstrated a particle size of 265.45 nm and an entrapment efficiency of 76.45%. In vitro dissolution studies revealed a cumulative drug release of 98.85% over 12 hours, with the release kinetics fitting the Korsmeyer-Peppas model (R² = 0.9535). These results indicate the potential of phospholipid complexes in enhancing the therapeutic efficacy of Piper cubeba, warranting further investigation into their clinical applications.
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