FORMULATION AND CHARACTERIZATION OF CUBOSOMES OF ISOCONAZOLE FOR TOPICAL DISEASE
Vaishnavi Arya, Rajeev Kumar Malviya
ABSTRACT
This study focuses on the formulation and characterization of Cubosomes loaded with Isoconazole for enhanced topical drug delivery. Cubosomal dispersions were prepared using Glyceryl monooleate (GMO) and Poloxamer 407 via a top-down technique. Isoconazole was incorporated into the dispersion, and formulations were optimized to maximize drug entrapment efficiency and minimize particle size. The optimal formulation was then integrated into a gel matrix using Carbomer, Triethanolamine (TEA), and propylene glycol to achieve a stable Cubosomal gel. Characterization studies included evaluation of particle size, entrapment efficiency, drug release kinetics, and physical properties of the gel formulations. In vitro drug release studies demonstrated sustained release profiles, and regression analysis indicated the Korsmeyer-Peppas model best described the release kinetics. The findings highlight the potential of Cubosomal technology for improving Isoconazole delivery in dermatological applications.
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