DEVELOPMENT AND CHARACTERIZATION OF LIPOSPHERE ENCAPSULATING DEXLANSAPRAZOLE FOR ENHANCED BIOAVAILABILITY
Sunil Uchadiya, Rajeev Kumar Malviya
ABSTRACT
This study focuses on the development and characterization of lipospheres encapsulating dexlansoprazole, aimed at enhancing its bioavailability. Various formulations were prepared, and their yield and drug entrapment efficiency were assessed. Among the tested formulations, F3 exhibited the highest percentage yield of 89.95% and an entrapment efficiency of 76.45%. Flow properties indicated favorable characteristics for formulations F1, F3, and F4, essential for uniformity in dosage. In vitro release studies demonstrated a sustained release profile for formulation F3, with 98.74% cumulative drug release over 12 hours, adhering to first-order kinetics. These findings suggest that the developed lipospheres are promising candidates for improving the bioavailability of dexlansoprazole, paving the way for enhanced therapeutic outcomes.
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