FORMULATION AND CHARACTERIZATION OF VELPATASVIR INSTANT RELEASE AND SOFOSBUVIR CONTROL RELEASE BILAYER TABLETS
Nagendra Kumar Tripathi, Muraree Lal, Avinash Krishnarao Kondalkar
ABSTRACT
The formulation and characterization of bilayer tablets containing Sofosbuvir and Velpatasvir mark a significant advancement in pharmaceutical innovation aimed at improving hepatitis C treatment efficacy. This bilayer tablet design facilitates controlled and synergistic drug release, tailored to the distinct pharmacokinetic profiles of both active ingredients. Extensive optimization of pharmaceutical parameters including tablet thickness, hardness, friability, weight uniformity, and drug content was conducted to ensure the tablets' quality and uniformity. In-vitro dissolution studies revealed a well-defined release profile, showcasing differentiated release kinetics for Sofosbuvir and Velpatasvir across simulated physiological conditions. This formulation demonstrates robust pharmaceutical attributes, promising consistent quality and performance critical for enhancing therapeutic outcomes in hepatitis C management.
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