A CURRENT REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM
Nemat Fatima, Samreen Ali
ABSTRACT
Oral route is the most appropriate and preferred route for systemic or local delivery of any drug. The gastro retentive dosage forms (GRDFs) is a very long-term time used to improve treatment with several important drugs. To overcome these limitations, various approaches have been proposed to increase the gastric retention time of the delivery system in the upper part of gastrointestinal tract. Gastroretentive dosage form (GRDF) prolongs the GRT by targeting site-specific drug release in upper part of GIT. To formulate GRDDS various approaches like floating drug delivery systems, non-effervescent drug delivery systems, high density drug delivery systems, bioadhesive systems, magnetic systems, expandable systems etc. The purpose of this article is to compile the recent literature with special focus on various gastroretentive approaches and examined with their advantages and disadvantages. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Finally the evaluation parameters of gastroretentive drug delivery systems and their application are covered in detail. Although tremendous advances have been seen in oral controlled drug delivery system in the last two decades, this system has been of limited success in the case of drugs with a poor absorption window throughout the GIT (Gastro Intestinal Tract).
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