FORMULATION AND EVALUATION OF GLIMEPIRIDE DRUG LOADED MUCOADHESIVE NANOPARTICLES FOR TREATMENT OF DIABETES
Sadab Khan, Yashwant Singh Jat, Sunil Kumar Jain
ABSTRACT
This study explores the formulation and evaluation of Glimepiride-loaded mucoadhesive solid lipid nanoparticles (SLNs) for enhanced diabetes treatment. Utilizing chitosan as a mucoadhesive agent, Glimepiride nanoparticles were prepared through the ionotropic gelation method, ensuring optimized drug loading and sustained release. Various formulations were assessed for percentage yield, entrapment efficiency, and stability under acidic conditions. Formulation F3 emerged as the most effective, demonstrating a high percentage yield of 74.45% and an entrapment efficiency of 73.54%. Stability tests in 0.1 N HCl revealed formulation F3 maintained structural integrity, with transmittance decreasing from 65.25% at 2 hours to 15.45% at 12 hours. In vitro drug release studies showed that F3 provided a controlled release profile, with 98.85% of Glimepiride released over 12 hours. The formulation's drug release followed zero-order kinetics, indicating a sustained release mechanism. These results suggest that Glimepiride-loaded mucoadhesive chitosan nanoparticles, particularly formulation F3, hold significant potential for improving the management of diabetes through controlled drug delivery and enhanced therapeutic efficacy.
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