International Journal of Pharmaceutics & Drug Research

Nitesh Yadav, Satkar Prasad

ABSTRACT

Fungal infections represent a significant burden globally, necessitating effective topical treatments that can penetrate the skin barrier to deliver therapeutic agents efficiently. Ethosomal gels have garnered attention as advanced drug delivery systems due to their ability to enhance drug permeation and bioavailability. This review provides an in-depth analysis of the formulation and characterization of antifungal ethosomal gels designed for topical fungal treatment. It explores the fundamental principles of ethosomal vesicles, emphasizing their composition, structure, and mechanisms facilitating enhanced drug delivery across the skin. The review discusses formulation strategies, including lipid composition, ethanol content, and incorporation of antifungal agents, highlighting their impact on vesicle stability, drug loading efficiency, and therapeutic efficacy. Furthermore, characterization techniques such as particle size analysis, zeta potential measurement, and morphological examination are evaluated for their role in assessing the physical properties and stability of ethosomal formulations. Recent advancements in optimizing ethosomal gel formulations for improved antifungal activity, stability, and patient compliance are reviewed, along with challenges and future directions in the field. By synthesizing current research findings, this review aims to provide comprehensive insights into the development and application of antifungal ethosomal gels, addressing key considerations for advancing topical fungal treatment strategies.

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