REVIEW ON FORMULATION AND EVALUATION OF OCULAR IN SITU GEL
Km Priti, Satkar Prasad
ABSTRACT
In situ gel formulations have emerged as promising vehicles for ocular drug delivery due to their ability to undergo phase transition from liquid to gel upon application, thereby prolonging drug residence time and enhancing bioavailability. This review explores the development, characterization, and clinical applications of in situ gels in ophthalmic treatments, highlighting their advantages over conventional eye drops. Key aspects including formulation strategies, evaluation parameters such as rheology and drug release kinetics, clinical efficacy, and challenges like stability and ocular irritation are discussed. Despite their potential, ongoing research is needed to address existing limitations and optimize these formulations for broader therapeutic use in treating ocular diseases.
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