ECO FRIENDLY METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF NABUMETONE USING MIXED HYDROTROPIC PHENOMENA
Abhijeet Kumar, Munesh Singh Bhadauria, Avinash Krishnarao Kondalkar, Muraree Lal
ABSTRACT
The development of an eco-friendly method for the estimation of nabumetone (NBT) using mixed hydrotropic phenomena is presented. This study aims to provide a sustainable analytical approach by leveraging hydrotropic solutions, which enhance the solubility of poorly soluble compounds like nabumetone. The method was validated through linearity, accuracy, precision, and recovery studies. Results showed that the method adheres to Beer’s law within the concentration range of 10-50 ?g/ml, with a high correlation coefficient (r² = 0.999). Recovery studies from marketed formulations indicated accuracy with recovery rates of 98.648% to 99.044%. Validation results demonstrated excellent precision with relative standard deviations ranging from 0.115% to 0.225%. Analysis of a tablet sample revealed a label claim percentage of 99.13%, confirming the method’s effectiveness. The proposed method is not only reliable but also environmentally friendly, making it a viable alternative for routine analysis of nabumetone in pharmaceutical formulations.
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