DEVELOPMENT AND CHARACTERIZATION OF DRUG PHOSPHOLIPID COMPLEX FOR IMPROVED SOLUBILITY OF CEFIXIME
Shivani Tamrakar, Dr. Yashwant Singh Jat, Dr. Sunil Kumar Jain
ABSTRACT
The development of phospholipid complexes for the oral administration of Cefixime, a BCS class II drug, aims to enhance its solubility and controlled release profile. This study focuses on the formulation and characterization of phospholipid complexes designed to improve the drug’s therapeutic efficacy and patient compliance. Phospholipid complexes were prepared using various formulations and characterized for drug content, entrapment efficiency, particle size, zeta potential, and drug release profiles. Results revealed that formulation F4 exhibited the highest drug content (98.848%) and entrapment efficiency (89.909%). Particle size analysis indicated favorable characteristics for improved solubility, while zeta potential measurements suggested good stability of the phospholipid dispersions. The drug release study demonstrated a sustained release pattern for formulation F4, with 75.758% of cefixime released over 24 hours compared to the pure drug’s significantly lower release. Kinetic studies indicated that the drug release followed first-order kinetics, suggesting a controlled release mechanism. These findings highlight the effectiveness of phospholipid complexation in enhancing cefixime’s solubility and release profile, potentially leading to better therapeutic outcomes.
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