ENHANCEMENT OF DISSOLUTION RATE AND DEVELOPMENT OF FAST DISSOLVING TABLET OF VERICIGUAT
Rakesh Kumar Pandey, Priti Singh, Ashish Manigauha
ABSTRACT
The development of fast dissolving tablets (FDTs) for Vericiguat, a soluble guanylate cyclase stimulator used in heart failure treatment, addresses the challenge of its poor solubility and dissolution rate. This study explores the enhancement of Vericiguat’s dissolution rate through the formulation of FDTs using various ratios of PEG 4000. The physical mixture’s dissolution performance was evaluated, revealing significant improvements with higher polymer ratios. The study also assessed drug content, pre-compression parameters, post-compression characteristics, and in-vitro disintegration and drug release profiles. Formulation F4 emerged as the most effective, showing optimal drug release, with 96.65% dissolution within 15 minutes and a first-order release profile. These findings highlight the successful application of advanced formulation techniques to enhance the dissolution rate and therapeutic efficacy of Vericiguat.
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