INVESTIGATION OF THE PHYTOCHEMICAL ANALYSIS AND IN VIVO ANTIPYRETIC ACTIVITY OF WITHANIA COAGULANS
Roshni Vishwakarma, Ankita Chaurasiya
ABSTRACT
This study investigates the phytochemical profile and in vivo antipyretic activity of Withania coagulans, a medicinal plant known for its therapeutic properties. Phytochemical screening of the ethanolic extract revealed the presence of phenolic compounds, proteins, and saponins, while alkaloids, glycosides, and flavonoids were absent. The extract demonstrated a total flavonoid content of 0.62 mg/100 mg and a total phenol content of 0.74 mg/100 mg. In vivo studies conducted on albino Wistar rats evaluated the antipyretic effect of the ethanolic extract using a yeast-induced pyrexia model. The extract, administered at doses of 250 mg/kg and 350 mg/kg, showed a significant reduction in rectal temperature compared to the control group. The antipyretic effect was comparable to paracetamol, a standard antipyretic drug, highlighting the potential of Withania coagulans as an effective antipyretic agent. These findings support the traditional use of this plant in fever management and provide a basis for further research into its therapeutic applications.
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