IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION AND EVALUATION OF CAPSAICIN LOADED LIPOSOMAL GEL FOR TREATMENT OF ALOPECIA

Rakhi Gupta, Sunil Kumar Jain, Yashwant singh Jat

ABSTRACT

In this study, Capsaicin loaded liposomal formulations were extensively evaluated for their potential as drug delivery systems, focusing on vesicle size, entrapment efficiency, in-vitro drug release, and stability. The vesicle size analysis revealed that formulations F1 to F6 ranged from 125.65 nm to 195.65 nm, with formulations F4 and F5 exhibiting sizes within the optimal range of 100-200 nm. Formulation F4, with a vesicle size of 125.65 nm, stood out for its superior entrapment efficiency of 74.65%, indicating efficient encapsulation of the drug compared to other formulations. The evaluation of liposomal gel formulations highlighted G2 as particularly promising due to its sustained drug release characteristics over a 10-hour period. The formulation exhibited an initial burst release within the first hour (46.65%) followed by a gradual release, achieving nearly complete drug release (98.85%) by the 10th hour. This sustained release profile is advantageous for topical applications, ensuring prolonged therapeutic efficacy and potentially reducing dosing frequency. Regression analysis of formulation G2 confirmed its suitability for controlled drug release, with high coefficients of determination (R²) for Zero Order (0.9539), First Order (0.8504), Higuchi's Model (0.9877), and Korsmeyer Peppas Equation (0.9877). Furthermore, stability studies conducted under controlled temperature conditions (4.0 ± 0.5°C and 28 ± 0.5ºC) for four weeks demonstrated no significant changes in physical appearance, average particle size, or drug content of the liposomal gel formulation. This stability profile indicates the formulation's robustness and potential for long-term storage without compromising its efficacy. In conclusion, the optimized liposomal gel formulation, particularly G2, shows promise as a viable platform for sustained drug delivery, offering controlled release characteristics and stability suitable for various pharmaceutical and biomedical applications.

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