FORMULATION AND EVALUATION OF LIPID BASED VESICULAR SYSTEM ETHOSOMES FOR TREATMENT OF SKIN INFECTION
Suruchi Jain, Sunil Kumar Jain, Yashwant Singh Jat
ABSTRACT
This study investigates the formulation and evaluation of lipid-based ethosomes loaded with Linezolid for the treatment of skin infections. Ethosomes were prepared and characterized for vesicle size, entrapment efficiency, and stability. Among the formulations tested, F5 emerged as the optimized formulation with a vesicle size of 110.25 nm and an entrapment efficiency of 85.45%. The selected ethosome formulation (EF2) was incorporated into a gel base, evaluated for physical characteristics including pH, viscosity, and drug content, as well as practical properties such as spreadability and extrudability. EF2 exhibited favorable attributes, including a pH of 6.74, viscosity of 3315 cps, and 98.12% drug content, alongside good spreadability and extrudability. In vitro drug release studies demonstrated sustained release kinetics over 10 hours, fitting well with zero-order and Pappas plot models. These findings highlight EF2 as a promising candidate for topical delivery of Linezolid, with potential implications for enhanced treatment outcomes in dermatological conditions.
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