PREPARATION, OPTIMIZATION AND CHARACTERIZATION OF NATEGLINIDE CONTAINING MICROSPHERES IN DIABETES
1Sudesh Kushwaha*,2 Shubham Patel, 2Gajendra Sen, 2Jyoti Sen, 2Abhishek Rawat, 1Yuvraj Singh Dangi, 2 Shailendra Patil
ABSTRACT
Gastroretentive drug delivery systems have made it possible to deliver the drugs in the stomach for prolonged period of time. Thus it is envisaged to develop a mucoadhesive microspheres based drug delivery system, which can be retained in the stomach for prolonged period of time by virtue of their mucoadhesive properties. The intimate contact of the mucoadhesive polymer with the mucous surface can result in an increased drug retention time and drug concentration in the GI tract. Nateglinide is a oral anti-diabetic drug used in Type-II diabetes (non-insulin dependent diabetes mellitus) that can acutely lower the blood glucose level in humans by stimulation the release of insulin from the pancreas. Its short biological half life (1-1.5 hours) necessitates that it be administered in 2 or 3 doses of 60 to 120 mg of per day. Moreover, the site of absorption of nateglinide is in the stomach. Thus the development of mucoadhesive controlled-release microspheres would be eliminating the entire problem associated with drug.
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