PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIULCER ACTIVITY OF MEDICINAL PLANT PISTACIA INTEGERRIMA
Md Tanveerul Haque, Brijesh Sirohi, Shailendra Kumar Lariya
ABSTRACT
This study investigates the anti-ulcerogenic potential of Pistacia integerrima bark extract using a rat model exposed to ulcerogenic agents. The hydroalcoholic extract of Pistacia integerrima demonstrated a yield of 8.5% w/w and was characterized for its phytochemical composition, revealing the presence of carbohydrates, proteins, diterpenes, saponins, flavonoids, and tannins & phenols. Quantitative analysis identified 0.425 mg of total phenols and 0.759 mg of total flavonoids per 100 mg of extract. In the experimental evaluation, Pistacia integerrima bark extract significantly reduced the number of ulcers and ulcer index in treated groups compared to controls. Group III exhibited the most pronounced effects with the lowest number of ulcers (1.55 ± 0.50) and ulcer index (0.80 ± 0.21), alongside elevated gastric pH (6.75 ± 0.65). These results suggest a dose-dependent response and highlight the extract's potential in mitigating ulcer formation by enhancing mucosal defense and modulating gastric acidity.
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