FLUCONAZOLE LOADED SOLID LIPID NANOPARTICLES AS POTENTIAL CARRIER FOR BUCCAL DRUG DELIVERY FOR ORAL CANDIDIASIS TREATMENT
Nidhi Soni, Rupesh K. Jain
ABSTRACT
The aim of present work was to develop and evaluate Fluconazole loaded solid lipid nanoparticles (SLNs) based gel for buccal drug delivery for the treatment of Oral candidiasis. Fluconazole (FZ) is an azole antifungal agent having broad spectrum activity against dermatophytes, moulds, yeasts, fungi. Fluconazole loaded SLNs systems were developed by Solvent injection method using Glycerol monostearate (GMS) as a solid lipid and Tween 80 as a surfactant. Developed SLNs were evaluated for particle shape and size, polydispersity index (PI), entrapment efficiency (EE) and drug release profiles. Process and formulation parameters were optimized. The FZ- SLNs based gel was prepared using Carbopol 934 as a gelling agent. The SLNs based gels were evaluated for physical appearance, pH determination, spread-ability, drug content and stability studies, in vitro drug release. Transmission electron microscopy confirmed that FZ-loaded SLNs were spherical. The particle size of the FZ-loaded SLNs was in the nano range of 203±5.5 nm which is suitable for drug penetration through buccal mucosa. The polydispersity index (PDI) showed a relatively narrow size distribution and was found to be in the range of 0.154- 0.201 and Zeta potential was found to be negatively charged which was -21.6. The entrapment efficiency was found to be84.3%. Thus, the study concludes that SLNs based gel of FZ gives a sustained release profile of FZ and has the potential for promising drug delivery carrier for local and systemic treatment of Oral candidiasis through the buccal mucosa.
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