STUDY OF HISTAMINERGIC TRANSMISSION DURING SOCIAL INTERACTION IN MICE
Ashish Pal, Lokesh Verma, Jitendra Banweer
ABSTRACT
This study investigates the role of histaminergic transmission in social interaction and locomotor activity in mice. Histamine analogues, L-histidine, and histamine receptor antagonists were administered to male Swiss albino mice, and their effects on sociability and locomotion were examined using standardized behavioral assays. Histamine precursor L-histidine significantly increased sociability, while histamine receptor antagonists, cetirizine and ranitidine, reduced social behavior. Combination treatments of L-histidine with histamine receptor antagonists showed nuanced effects on sociability, suggesting complex interactions within the histaminergic system. Additionally, histaminergic analogues exerted diverse effects on locomotor activity, with implications for motor behavior regulation. These findings highlight the multifaceted role of histaminergic signaling in modulating social behavior and locomotion, providing insights into potential therapeutic interventions for conditions involving social dysfunction and motor impairments.
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